108432 – ATHEROSCLEROSIS, DEEP VEIN THROMBOSIS AND CHRONIC VENOUS INSUFFICIENCY: IS THERE A LINK? A CASE – CONTROL STUDY

Presenter:

JOSE PATRICIO PESENTI ANJEL

Approved Modality:

E-Poster Young Researcher – Non-case Report

Abstract:

Introduction: Atherosclerosis, deep vein thrombosis (DVT) and chronic venous insufficiency (CVI) have been seen as different entities, however thrombo-inflammation could be the link between them. In this study we explore this relationship in patients with DVT, CVI and controls. Methods: We recruited 7 patients with DVT and 9 with CVI from the Vascular Surgery Department of our University Hospital and 9 healthy controls matched for gender and age. We registered their cardiovascular risk factors and obtained blood tests for hs-CRP, Circulating Endothelial Cells (CEC), ICAM-1 and CXCL7 as biomarkers of inflammation, endothelial and platelets activation. Carotids plaques were classified according to the AHA MRI classification. We used Principal Component Analysis (PCA) and Hierarchical Clustering Analysis (HCA) to study the combined effect of all variables. Results: There were no significant differences between the groups for inflammatory markers and cardiovascular risk factors (Fig.A). However, using PCA and HCA we identified 2 clusters: cluster 1 with all the controls, one DVT and three CVI patients; and cluster 2 with only DVT and CVI subjects (Fig.B). There was a significant difference between carotid plaque complexity between both clusters (Fig.C). Conclusions: Our study supports the link between inflammation, DVT and atherosclerosis, and contributes to consider CVI as another risk factor for atherosclerosis. Acknowledgment: FONDECYT 1180525

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